http://www.cgmage.com/designerjewelrycreations.com/cross-chain/
Combatting HIV, SARS (Carnegie Mellon)
Carnegie Mellon University chemists have created a synthetic form of a cyclic
peptide known for its remarkable ability to combat a wide variety of
pathogens, including HIV and SARS.
Synthetic peptides like the one developed at Carnegie Mellon could provide an
exciting new class of pharmaceuticals aimed at combatting hard-to-treat
diseases.
Furthermore, the manufacturing technique developed by Associate Professor of
Chemistry Danith Ly could further the study of cyclic peptides by making the
molecules easier and less expensive to produce.
Peptides are short chains of amino acids joined together by peptide bonds.
They can be arranged in a linear chain or in a ring that is held together at
the center by cross-linked bonds.
Scientists have explored the therapeutic potential of peptides for decades.
“The problem with peptides is that they’re small and floppy and, when they
bind, they don’t bind with high affinity or selectivity. If you take a linear
peptide and inject it into the bloodstream the half-life is less than two
minutes,” said Ly, who is a member of CMU’s Center for Nucleic Acids Science
and Technology.
“Nature gets around this by making peptides circular. In addition, if you
inject a cyclic peptide into the blood …
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